Pressure is proinflammatory in lung venular capillaries

Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries.

Elevation of lung capillary pressure causes exocytosis of the leukocyte adhesion receptor P-selectin in endothelial cells (ECs), indicating that lung ECs generate a proinflammatory response to pressure-induced stress. To define underlying mechanisms, we followed the EC signaling sequence leading to P-selectin exocytosis through application of real-time, in situ fluorescence microscopy in lung c...

Responses in Lung Venular Capillaries Regulate Spatial Profile of Proinflammatory Mitochondrial Reactive Oxygen Species

Connexin 43 mediates spread of Ca2+-dependent proinflammatory responses in lung capillaries.

Acute lung injury (ALI), which is associated with a mortality of 30-40%, is attributable to inflammation that develops rapidly across the lung's vast vascular surface, involving an entire lung or even both lungs. No specific mechanism explains this extensive inflammatory spread, probably because of the lack of approaches for detecting signal conduction in lung capillaries. Here, we addressed th...

Mechanotransduction in the Lung Pressure-induced endothelial Ca oscillations in lung capillaries

Kuebler, Wolfgang M., Xiaoyou Ying, and Jahar Bhattacharya. Pressure-induced endothelial Ca2 oscillations in lung capillaries. Am J Physiol Lung Cell Mol Physiol 282: L917–L923, 2002; 10.1152/ajplung.00275.2001.—Endothelial second messenger responses may contribute to the pathology of high vascular pressure but remain poorly understood because of the lack of direct in situ quantification. In lu...

Coronary venular responses to flow and pressure.

In previous studies, we demonstrated that both endothelium-dependent flow-induced vasodilation and endothelium-independent myogenic responses occur in porcine coronary arterioles. However, it was not established whether these responses are present in the coronary venular microcirculation. The aim of this study was to test the hypotheses that 1) coronary venules, like arterioles, exhibit flow-in...